Faculty Directory
David Lo
Distinguished Professor of Biomedical Sciences
Ph.D., University of Pennsylvania, Philadelphia
M.D., University of Pennsylvania, Philadelphia
Postdoctorate, University of Pennsylvania School of Veterinary Medicine, Philadelphia
Contact Info
Office: (951) 827-4553
Fax: (951) 827-5504
e-mail: david.lo@ucr.edu
Research Interests
Research in my laboratory is concerned with the study of the basic developmental biology of mucosal immune tissue, CD4 T cell homeostatic regulation, and the role of relB in the regulation of NF-kappaB activity and cellular differentiation. One of our major projects is on the development and function of M cells, which are a specialized subset of epithelial cells associated with mucosal immune tissues. These cells are responsible for the surveillance of the airway and intestine, by performing a selective sampling of particles from the lumen. We are working to use this system to develop a needle-free vaccine delivery technology that may be conveniently and cheaply applied to vaccination against infectious agents such as influenza. A second major project is focused on the role of the chemokine receptor CCR7 in the regulation of CD4 T cell survival and differentiation. Our studies have suggested that CCR7 ligands regulate not only lymphocyte migration, but also their survival and development into effector cells.
Selected Publications
Castiglioni, P., Lu, C., Lo, D., Croft, M., Langlade-Demoyen, P., Zanetti, M., and Gerloni, M., CD4 T cell priming in dendritic cell-deficient mice. Intl. Immunol. 15:127-136, 2003.
Fan, L., Busser, B.W., Lifsted, T.Q., Lo, D., Laufer, T.M., Antigen presentation by keratinocytes directs autoimmune skin disease. Proc. Natl. Acad. Sci. USA 100:3386-91, 2003.
Elewaut, D., Shaikh, R.B., Hammond, K.J.L., De Winter, H., Leishman, A.J., Sidobre, S., Turovskaya, O., Prigozy, T.I., Ma, L., Banks, T.A., Lo, D., Ware, C.F., Cheroutre, H. and Kronenberg, M., NIK dependent RelB activation defines a unique signaling pathway for the development of Va14i cells. J. Exp. Med. 197:162333, 2003.
Lo, D., Tynan, W., Dickerson, J., Mendy, J., Chang, H.-W., Scharf, M., Byrne, D., Brayden, D., Higgins, L., Evans, C., O'Mahony, D.J., Peptidoglycan recognition protein expression in mouse Peyer's patch Follicle Associated Epithelium suggests functional specialization. Cell. Immunol. 224:8-16, 2003.
Lemos, M.P., Fan, L., Lo, D., Laufer, T.M., CD8a+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity. J. Immunol. 171:5077-5084, 2003. Thomas, E.A., George, R., Danielson, P., Nelson, P.A., Warren, A.J., Lo, D., and Sutcliffe, J.G., Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins. Molecular Psychiatry 8:983-93, 2003.
Lo, D., Tynan, W., Dickerson, J., Scharf, M., Cooper, J., Byrne, D., Brayden, D., Higgins, L., Evans, C., and O'Mahony, D.J., Cell culture modeling of specialized tissue: Identification of genes expressed specifically by Follicle Associated Epithelium of Peyer's Patch by expression profiling of Caco-2/Raji co-cultures. Intl. Immunol. 16:91-99, 2004.
Carson, M.J., Thrash, J.C., Lo, D., Analysis of microglial gene expression: Toward targeted therapies for CNS neurodegenerative and autoimmune disease. Amer. J. Pharmacogenomics 4:321-30, 2004.
Lo, D., Exploiting immune surveillance mechanisms in mucosal vaccine development. Expert Opin. Biol. Therapy 4:397-406, 2004.
Broide, R.S., Trembleau, A., Ellison, J.A., Cooper, J., Lo, D., Young, W.G., Morrison, J.H., and Bloom, F.E., Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR. Brain Res. 1000:211-22, 2004.
Pauza, M.E., Dobbs, C.M., He, J. Patterson, T., Wagner, S., Anobile, B.S., Bradley, B.J., Lo, D., Haskins, K., T-Cell Receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. Diabetes 53:978-988, 2004.
Spence, J., Liang, T., Foroud, T., Lo, D., Carr, L.G., Total Gene Expression Analysis (TOGA): A complementary approach to QTL analysis in selected rat strains. Addiction Biology 10:47-51, 2005.
Goldfine, A.B., Crunkhorn, S., Costello, M., Gami, H., Landaker, E.J., Niinobe, M., Yoshikawa, K., Lo, D., Warren, A., Jimenez-Chillaron, J., and Patti, M.E., Necdin and E2F-4 are targets of rosiglitazone therapy in diabetic human adipose and muscle tissues. Diabetes, 55:640-650, 2006.